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Sarcoidosis

Sarcoidosis is a disease in which inflammation occurs in the lymph nodes, lungs, liver, eyes, skin, and/or other tissues.

The exact cause of sarcoidosis is unknown. What is known is that when a person has the disease, tiny clumps of abnormal tissue (granulomas) form in certain organs of the body. Granulomas are clusters of immune cells.

The disease can affect almost any organ. It most commonly affects the lungs.

Doctors think that having certain genes makes it more likely for a person to develop sarcoidosis. Things that may trigger the disease include infections with bacteria or viruses. Contact with dust or chemicals may also be triggers.

The disease is more common in African Americans and white people of Scandinavian heritage. More women than men have the disease.

The disease often begins between ages 20 and 40. Sarcoidosis is rare in young children.

A person with a close blood relative who has sarcoidosis is nearly 5 times as likely to develop the condition.

Symptoms

There may be no symptoms. When symptoms do occur, they can involve almost any body part or organ system.

Almost all people affected by sarcoidosis have lung or chest symptoms:

  • Chest pain (most often behind the breast bone)
  • Dry cough
  • Shortness of breath
  • Coughing up blood (rare, but serious)

Symptoms of general discomfort may include:

Skin symptoms may include:

Nervous system symptoms may include:

  • Headache
  • Seizures
  • Weakness on one side of the face

Eye symptoms may include:

  • Burning
  • Discharge from the eye
  • Dry eyes
  • Itching
  • Pain
  • Vision loss

Other symptoms of this disease may include:

  • Dry mouth
  • Fainting spells, if the heart is involved
  • Nosebleed
  • Swelling in the upper part of the abdomen
  • Liver disease
  • Swelling of the legs if heart and lungs are involved
  • Abnormal heart rhythm if the heart is involved

Exams and Tests

The health care provider will perform a physical examination and ask about the symptoms.

Different imaging tests may help diagnose sarcoidosis:

To diagnose this condition, a biopsy is needed. Biopsy of the lung using bronchoscopy is usually done. Biopsies of other body tissues may also be done.

The following lab tests may be done:

Treatment

Sarcoidosis symptoms will often get better without treatment.

If the eyes, heart, nervous system, or lungs are affected, corticosteroids are usually prescribed. This medicine may need to be taken for 1 to 2 years.

Medicines that suppress the immune system are sometimes also needed.

In rare cases, people with very severe heart or lung damage (end-stage disease) may need an organ transplant.

Outlook (Prognosis)

Many people with sarcoidosis are not seriously ill, and get better without treatment. Up to half of all people with the disease get better in 3 years without treatment. People whose lungs are affected may develop lung damage.

Overall death rate from sarcoidosis is less than 5%. Causes of death include:

  • Bleeding from the lung tissue
  • Heart damage, leading to heart failure and abnormal heart rhythms
  • Lung scarring (pulmonary fibrosis)

Possible Complications

Sarcoidosis may lead to these health problems:

  • Fungal lung infections (aspergillosis)
  • Glaucoma and blindness from uveitis (rare)
  • Kidney stones from high calcium levels in blood or urine
  • Osteoporosis and other complications of taking corticosteroids for long periods of time
  • High blood pressure in the arteries of the lungs (pulmonary hypertension)

When to Contact a Medical Professional

Call your provider promptly if you have:

References

Judson MA, Morgenthau AS, Baughman RP. Sarcoidosis. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 66.

Soto-Gomez N, Peters JI, Nambiar AM. Diagnosis and management of sarcoidosis. Am Fam Physician. 2016;93(10):840-848. PMID: 27175719 www.ncbi.nlm.nih.gov/pubmed/27175719.

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  • Sarcoid, stage I - chest X-ray

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  • Sarcoid, stage II - chest X-ray

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  • Sarcoid, stage IV - chest X-ray

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  • Sarcoid - close-up of the skin lesions

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  • Erythema nodosum associated with sarcoidosis

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  • Sarcoidosis - close-up

    Sarcoidosis - close-up

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  • Sarcoidosis on the elbow

    Sarcoidosis on the elbow

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  • Sarcoidosis on the nose and forehead

    Sarcoidosis on the nose ...

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  • Respiratory system

    Respiratory system

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  • Erythema nodosum associated with sarcoidosis

    Erythema nodosum associa...

    illustration

    • Sarcoid, stage I - chest X-ray

      Sarcoid, stage I - chest...

      illustration

    • Sarcoid, stage II - chest X-ray

      Sarcoid, stage II - ches...

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    • Sarcoid, stage IV - chest X-ray

      Sarcoid, stage IV - ches...

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    • Sarcoid - close-up of the skin lesions

      Sarcoid - close-up of th...

      illustration

    • Erythema nodosum associated with sarcoidosis

      Erythema nodosum associa...

      illustration

    • Sarcoidosis - close-up

      Sarcoidosis - close-up

      illustration

    • Sarcoidosis on the elbow

      Sarcoidosis on the elbow

      illustration

    • Sarcoidosis on the nose and forehead

      Sarcoidosis on the nose ...

      illustration

    • Respiratory system

      Respiratory system

      illustration

    • Erythema nodosum associated with sarcoidosis

      Erythema nodosum associa...

      illustration

     

    Review Date: 5/21/2017

    Reviewed By: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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